The Joplin Regional Airport is a commercial service airport with scheduled air carrier service and is considered a Primary Airport by the Federal Aviation Administration.

The Terminal is located at 7331 N. Highway 43, and can be accessed by traveling 1½ miles north of the intersection of 171 and 43. The Airport entrance is located on the east side.

Runways 13/31and 18/36 are defined as transport category runways and maintain a C-III Airport Reference Code. This Airport Reference Code accommodates aircraft with the following characteristics:

Aircraft approach speeds between 124 and 141 knots
Aircraft wingspan between 79 and 117 feet

These runway are designed to accommodate routine operations by aircraft as large as the Airbus A320 series, Boeing 737 series, and the Boeing MD80/MD90/717 series. Frequent aircraft operations are conducted by aircraft such as the Fairchild/Dornier 328Jet, Saab 340, and British Aerospace Jetstream 41/Super 31.

Runway 5/23 is defined as a general utility category runway and maintains an Airport Reference Code of A-I. This Airport Reference Code accommodates aircraft with the following characteristics:

Aircraft approach speeds less than 91 knots
Aircraft wingspan up to but not including 49 feet

This runway is designed to accommodate routine operations by most single and some light twin general aviation aircraft types.